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KMID : 0043320040270121211
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Archives of Pharmacal Research
2004 Volume.27 No. 12 p.1211 ~ p.1215
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Cytotoxic Coumarins from the Root of Angelica dahurica
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Thanh Pham Ngoc
Jin Wen-Yi
Song Gyu-Yong
Bae Ki-Hwan
Kang Sam-Sik
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Abstract
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Ten coumarins were isolated from the root of Angelica dahurica by repeated silica gel column chromatography. Their chemical structures were elucidated on the basic of physicochemical and spectroscopic data. Among them, oxypeucedanin hydrate acetonide (7) was isolated for the first time from this plant. Cytotoxicity of coumarins isolated were determined in vitro against L1210, HL-60, K562, and B16F10 tumor cell lines by MTT method. Pangelin (5) and oxypeucedanin hydrate acetonide (7) showed a potent cytotoxic activity with the values of 8.6 to 14.6 /mL against four kinds of tumor cell lines. Other compounds showed the moderate cytotoxic activity or no activity against the tumor cell lines.
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KEYWORD
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Angelica dahurica, Coumarins, Pangelin, Oxypeucedanin hydrate acetonide, Tumor cells, Cytotoxicity
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